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Investigación
Investigación sobre Anomalías Congénitas
Líneas de investigación
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Unidad de Epigenética y Regulación Génica
Regulación epigenética de la identidad el músculo estriado y su implicación en enfermedades raras del tipo de las miopatías idiopáticas y problemas de conducción cardiaca, tales como la fibrilación atrial y el bloqueo atrioventricular. Ensayos Funcionales de Nuevas Mutaciones en Enfermos no Diagnosticados.
Proyecto PID2020-114773GB-I00 (AEI/10.13039/501100011033) financiado por:
Publicaciones destacadas
Abós B, Wang T, Castro R, Granja AG, Leal E, Havixbeck J, Luque A, Barreda DR, Secombes CJ, Tafalla C. Distinct Differentiation Programs Triggered by IL-6 and LPS in Teleost IgM(+) B Cells in The Absence of Germinal Centers. Sci Rep. 2016 Aug 2;6:30004
Abós B, Wang T, Castro R, Granja AG, Leal E, Havixbeck J, Luque A, Barreda DR, Secombes CJ, Tafalla C. Distinct Differentiation Programs Triggered by IL-6 and LPS in Teleost IgM(+) B Cells in The Absence of Germinal Centers. Sci Rep. 2016 Aug 2;6:30004
PUBMED DOIMaría Luisa Franco, Cristina Melero, Esther Sarasola, Alfonso Luque, María García-Barcina and Marçal Vilar. Mutations in TrkA Causing Congenital Insensitivity to Pain with Anhidrosis (CIPA) Induce Mutation-Dependent Misfolding, Aggregation and Cell Death. J Biol Chem. 2016 Aug 22. pii: jbc.M116.722587
María Luisa Franco, Cristina Melero, Esther Sarasola, Alfonso Luque, María García-Barcina and Marçal Vilar. Mutations in TrkA Causing Congenital Insensitivity to Pain with Anhidrosis (CIPA) Induce Mutation-Dependent Misfolding, Aggregation and Cell Death. J Biol Chem. 2016 Aug 22. pii: jbc.M116.722587
PUBMED DOIα-Hispanolol sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis via death receptor up-regulation. Mota A, Jiménez-Garcia L, Herránz S, de Las Heras B, Hortelano S. Toxicol Appl Pharmacol. 2015 Aug 1;286(3):168-77.
α-Hispanolol sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis via death receptor up-regulation. Mota A, Jiménez-Garcia L, Herránz S, de Las Heras B, Hortelano S. Toxicol Appl Pharmacol. 2015 Aug 1;286(3):168-77.
PUBMED DOICritical role of p38 MAPK in IL-4-induced alternative activation of peritoneal macrophages. Jiménez-Garcia L, Herránz S, Luque A, Hortelano S. Eur J Immunol. 2015 Jan;45(1):273-86
Critical role of p38 MAPK in IL-4-induced alternative activation of peritoneal macrophages. Jiménez-Garcia L, Herránz S, Luque A, Hortelano S. Eur J Immunol. 2015 Jan;45(1):273-86
PUBMED DOIIL10 released by a new inflammation-regulated lentiviral system efficiently attenuates zymosan-induced arthritis. Garaulet G, Alfranca A, Torrente M, Escolano A, López-Fontal R, Hortelano S, Redondo JM, Rodríguez A. Mol Ther. 2013 Jan;21(1):119-30.
IL10 released by a new inflammation-regulated lentiviral system efficiently attenuates zymosan-induced arthritis. Garaulet G, Alfranca A, Torrente M, Escolano A, López-Fontal R, Hortelano S, Redondo JM, Rodríguez A. Mol Ther. 2013 Jan;21(1):119-30.
PUBMED DOICritical role of the death receptor pathway in the antitumoral effects induced by hispanolone derivatives. Través PG, López-Fontal R, Cuadrado I, Luque A, Boscá L, de las Heras B, Hortelano S. Oncogene. 2013 Jan 10;32(2):259-68.
Critical role of the death receptor pathway in the antitumoral effects induced by hispanolone derivatives. Través PG, López-Fontal R, Cuadrado I, Luque A, Boscá L, de las Heras B, Hortelano S. Oncogene. 2013 Jan 10;32(2):259-68.
PUBMED DOILaura Hidalgo, Beatriz Somovilla-Crespo, Patricia Garcia-Rodriguez, Alvaro Morales Molina, Miguel Angel Rodriguez-Milla, Javier Garcia-Castro. Switchable CAR T cell strategy against osteosarcoma. Cancer Immunol Immunother. 2023 Aug;72(8):2623-2633.
Laura Hidalgo, Beatriz Somovilla-Crespo, Patricia Garcia-Rodriguez, Alvaro Morales Molina, Miguel Angel Rodriguez-Milla, Javier Garcia-Castro. Switchable CAR T cell strategy against osteosarcoma. Cancer Immunol Immunother. 2023 Aug;72(8):2623-2633.
PUBMED DOIAlvaro Morales-Molina, Miguel Ángel Rodriguez-Milla, Stefano Gambera, Teresa Cejalvo, Belén de Andrés, María-Luisa Gaspar, Javier García-Castro. Toll-like Receptor Signaling-deficient Cells Enhance Antitumor Activity of Cell-basedImmunotherapy by Increasing Tumor Homing. Cancer Res Commun. 2023 Mar 1;3(3):347-360.
Alvaro Morales-Molina, Miguel Ángel Rodriguez-Milla, Stefano Gambera, Teresa Cejalvo, Belén de Andrés, María-Luisa Gaspar, Javier García-Castro. Toll-like Receptor Signaling-deficient Cells Enhance Antitumor Activity of Cell-basedImmunotherapy by Increasing Tumor Homing. Cancer Res Commun. 2023 Mar 1;3(3):347-360.
PUBMED DOIAna Cloquell, Isidro Mateo, Stefano Gambera, Martí Pumarola, Ramón Alemany, Javier Garcia-Castro, Judith Perisé-Barrios. Systemic cellular viroimmunotherapy for canine high-grade gliomas. J Immunother Cancer. 2022 Dec;10(12): e005669.
Ana Cloquell, Isidro Mateo, Stefano Gambera, Martí Pumarola, Ramón Alemany, Javier Garcia-Castro, Judith Perisé-Barrios. Systemic cellular viroimmunotherapy for canine high-grade gliomas. J Immunother Cancer. 2022 Dec;10(12): e005669.
PUBMED DOIClara Martín-Carrasco, Pablo Delgado-Bonet, Beatriz Davinia Tomeo-Martín, Josep Pastor, Claudia de la Riva, Paula Palau-Concejo, Noemí del Castillo, Javier García-Castro, Ana Judith Perisé-Barrios. Safety and Efficacy of an Oncolytic Adenovirus as an Immunotherapy for Canine Cancer Patients. Vet Sci. 2022 Jul; 9(7): 327
Clara Martín-Carrasco, Pablo Delgado-Bonet, Beatriz Davinia Tomeo-Martín, Josep Pastor, Claudia de la Riva, Paula Palau-Concejo, Noemí del Castillo, Javier García-Castro, Ana Judith Perisé-Barrios. Safety and Efficacy of an Oncolytic Adenovirus as an Immunotherapy for Canine Cancer Patients. Vet Sci. 2022 Jul; 9(7): 327
PUBMED DOIMarion Rabé, Lucie Fonteneau, Lisa Oliver, Alvaro Morales-Molina, Camille Jubelin, Javier Garcia-Castro, Dominique Heymann, Catherine Gratas, François M. Vallette. Cellular Heterogeneity and Cooperativity in Glioma Persister Cells Under Temozolomide Treatment Frontiers in Cell and Developmental Biology. 2022, 10; 835273.
Marion Rabé, Lucie Fonteneau, Lisa Oliver, Alvaro Morales-Molina, Camille Jubelin, Javier Garcia-Castro, Dominique Heymann, Catherine Gratas, François M. Vallette. Cellular Heterogeneity and Cooperativity in Glioma Persister Cells Under Temozolomide Treatment Frontiers in Cell and Developmental Biology. 2022, 10; 835273.
PUBMED DOIAlvaro Morales-Molina, Stefano Gambera, Angela Leo, Javier García-Castro Combination immunotherapy using G-CSF and oncolytic virotherapy reduces tumor growth in osteosarcoma. J Immunother Cancer. 2021 Mar;9(3): e001703.
Alvaro Morales-Molina, Stefano Gambera, Angela Leo, Javier García-Castro Combination immunotherapy using G-CSF and oncolytic virotherapy reduces tumor growth in osteosarcoma. J Immunother Cancer. 2021 Mar;9(3): e001703.
PUBMED DOIGambera S, Patiño-Garcia A, Alfranca A, Garcia-Castro J RGB-Marking to Identify Patterns of Selection and Neutral Evolution in Human Osteosarcoma Models. Cancers . 2021 Apr 21;13(9):2003.
Gambera S, Patiño-Garcia A, Alfranca A, Garcia-Castro J RGB-Marking to Identify Patterns of Selection and Neutral Evolution in Human Osteosarcoma Models. Cancers . 2021 Apr 21;13(9):2003.
PUBMED DOIHermida-Prieto M., García-Castro J., Mariñas-Pardo L. Systemic treatment of immune-mediated keratoconjunctivitis sicca with allogeneic stem cells improves the schirmer tear test score in a canine spontaneous model of disease. Journal of Clinical Medicine. 2021; 10(24): 5981.
Hermida-Prieto M., García-Castro J., Mariñas-Pardo L. Systemic treatment of immune-mediated keratoconjunctivitis sicca with allogeneic stem cells improves the schirmer tear test score in a canine spontaneous model of disease. Journal of Clinical Medicine. 2021; 10(24): 5981.
PUBMED DOIMiguel Ángel Rodríguez-Milla, Alvaro Morales-Molina, Ana Judith Perisé-Barrios, Teresa Cejalvo, Javier García-Castro. AKT and JUN are differentially activated in mesenchymal stem cells after infection with human and canine oncolytic adenoviruses. Cancer Gene Therapy, 2021, 28, 64–73.
Miguel Ángel Rodríguez-Milla, Alvaro Morales-Molina, Ana Judith Perisé-Barrios, Teresa Cejalvo, Javier García-Castro. AKT and JUN are differentially activated in mesenchymal stem cells after infection with human and canine oncolytic adenoviruses. Cancer Gene Therapy, 2021, 28, 64–73.
PUBMED DOIAna Judith Perisé-Barrios, Beatriz Davinia Tomeo-Martín, Pablo Gómez-Ochoa, Pablo Delgado-Bonet, Pedro Plaza, Paula Palau-Concejo, Jorge González, Gustavo Ortiz-Díez, Antonio Meléndez-Lazo, Michaela Gentil, Javier García-Castro, Alicia Barbero-Fernández. Humoral responses to SARS-CoV-2 by healthy and sick dogs during the COVID-19 pandemic in Spain. Vet Res. 2021 Feb 15;52(1):22.4
Ana Judith Perisé-Barrios, Beatriz Davinia Tomeo-Martín, Pablo Gómez-Ochoa, Pablo Delgado-Bonet, Pedro Plaza, Paula Palau-Concejo, Jorge González, Gustavo Ortiz-Díez, Antonio Meléndez-Lazo, Michaela Gentil, Javier García-Castro, Alicia Barbero-Fernández. Humoral responses to SARS-CoV-2 by healthy and sick dogs during the COVID-19 pandemic in Spain. Vet Res. 2021 Feb 15;52(1):22.4
PUBMED DOIDavid Ruano, José A. López-Martín, Lucas Moreno, Álvaro Lassaletta, Francisco Bautista, Maitane Andión, Carmen Hernández, África González-Murillo, Gustavo Melen, Ramón Alemany, Luis Madero, Javier García-Castro, Manuel Ramírez First-in-Human, First-in-Child Trial of Autologous MSCs Carrying the Oncolytic Virus Icovir-5 in Patients with Advanced Tumors Mol Ther. 2020 Apr 8; 28(4): 1033–1042.
David Ruano, José A. López-Martín, Lucas Moreno, Álvaro Lassaletta, Francisco Bautista, Maitane Andión, Carmen Hernández, África González-Murillo, Gustavo Melen, Ramón Alemany, Luis Madero, Javier García-Castro, Manuel Ramírez First-in-Human, First-in-Child Trial of Autologous MSCs Carrying the Oncolytic Virus Icovir-5 in Patients with Advanced Tumors Mol Ther. 2020 Apr 8; 28(4): 1033–1042.
PUBMED DOIThomas GP Grünewald, Marta Alonso, Sofia Avnet, Ana Banito, Stefan Burdach, Florencia Cidre‐Aranaz,Gemma Di Pompo, Martin Distel, Heathcliff Dorado‐Garcia, Javier Garcia‐Castro, Laura González‐González, Agamemnon E Grigoriadis, Merve Kasan, Christian Koelsche, Manuela Krumbholz, Fernando Lecanda, Silvia Lemma, Dario L Longo, Claudia Madrigal‐Esquivel, Álvaro Morales‐Molina, Julian Musa, Shunya Ohmura, Benjamin Ory, Miguel Pereira‐Silva, Francesca Perut, Rene Rodriguez, Carolin Seeling, Nada Al Shaaili, Shabnam Shaabani, Kristina Shiavone, Snehadri Sinha, Eleni M Tomazou, Marcel Trautmann, Maria Vela,Yvonne MH Versleijen‐Jonkers, Julia Visgauss, Marta Zalacain, Sebastian J Schober, Andrej Lissat, William R English, Nicola Baldini, Dominique Heymann. Sarcoma treatment in the era of molecular medicine EMBO Mol Med 2020; 12(11):e11131.
Thomas GP Grünewald, Marta Alonso, Sofia Avnet, Ana Banito, Stefan Burdach, Florencia Cidre‐Aranaz,Gemma Di Pompo, Martin Distel, Heathcliff Dorado‐Garcia, Javier Garcia‐Castro, Laura González‐González, Agamemnon E Grigoriadis, Merve Kasan, Christian Koelsche, Manuela Krumbholz, Fernando Lecanda, Silvia Lemma, Dario L Longo, Claudia Madrigal‐Esquivel, Álvaro Morales‐Molina, Julian Musa, Shunya Ohmura, Benjamin Ory, Miguel Pereira‐Silva, Francesca Perut, Rene Rodriguez, Carolin Seeling, Nada Al Shaaili, Shabnam Shaabani, Kristina Shiavone, Snehadri Sinha, Eleni M Tomazou, Marcel Trautmann, Maria Vela,Yvonne MH Versleijen‐Jonkers, Julia Visgauss, Marta Zalacain, Sebastian J Schober, Andrej Lissat, William R English, Nicola Baldini, Dominique Heymann. Sarcoma treatment in the era of molecular medicine EMBO Mol Med 2020; 12(11):e11131.
PUBMED DOIAlvaro Morales-Molina, Miguel Ángel Rodríguez-Milla, Alicia Gimenez-Sanchez, Ana Judith Perisé-Barrios, Javier García-Castro. Cellular Virotherapy Increases Tumor-Infiltrating Lymphocytes (TIL) and Decreases their PD-1+ Subsets in Mouse Immunocompetent Models Cancers 2020 Jul; 12(7): 1920.
Alvaro Morales-Molina, Miguel Ángel Rodríguez-Milla, Alicia Gimenez-Sanchez, Ana Judith Perisé-Barrios, Javier García-Castro. Cellular Virotherapy Increases Tumor-Infiltrating Lymphocytes (TIL) and Decreases their PD-1+ Subsets in Mouse Immunocompetent Models Cancers 2020 Jul; 12(7): 1920.
PUBMED DOIAna Gómez, David Sardón, Teresa Cejalvo, Fernando Vázquez, Javier García-Castro, Ana Judith Perisé-Barrios. Biodistribution Analysis of Oncolytic Adenoviruses in Canine Patient Necropsy Samples Treated with Cellular Virotherapy Molecular Therapy: Oncolytics Vol. 18 September 2020: 525-534.
Ana Gómez, David Sardón, Teresa Cejalvo, Fernando Vázquez, Javier García-Castro, Ana Judith Perisé-Barrios. Biodistribution Analysis of Oncolytic Adenoviruses in Canine Patient Necropsy Samples Treated with Cellular Virotherapy Molecular Therapy: Oncolytics Vol. 18 September 2020: 525-534.
PUBMED DOI