Genética Molecular

CREBBP/EP300 bromodomain inhibition affects the proliferation of AR positive breast cancer cell lines. (2019) Molecular Cancer Research. 17 (3): 720–730.

Garcia-Carpizo V, Ruiz-Llorente S, Sarmentero J, Gonzalez-Corpas A and Barrero MJ.

DOI

CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation. (2018) Epigenetics and Chromatin 11:30.

Garcia-Carpizo V, Ruiz-Llorente S, Sarmentero J, Graña O, Pisano DG and Barrero MJ.

DOI

NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation. (2016) Scientific Reports. 6:32952.

Garcia-Carpizo V, Sarmentero J, Han B, Graña O, Ruiz-Llorente S, Pisano DG, Serrano M, Brooks HB, Campbell RM, Barrero MJ.

DOI

SETD7 Regulates the Differentiation of Human Embryonic Stem Cells. (2016) PLoS One. 11(2): e0149502.

Castaño J, Morera C, Sesé B, Boue S, Bonet-Costa C, Martí M, Roque A, Jordan A, Barrero MJ.

DOI

Macro Histone Variants are Critical for the Differentiation of Human Pluripotent Cells. (2013) Journal of Biological Chemistry. 288(22):16110-6.

Barrero MJ, Sese B, Marti M and Izpisua Belmonte JC.

DOI

Macro Histone Variants Preserve Cell Identity by Preventing the Gain of H3K4me2 during Reprogramming to Pluripotency. (2013) Cell Reports 3, 1005–1011.

Barrero MJ, Sese B, Kuebler B, Bilic J, Boue S, Martí M, Belmonte JC.

DOI

Mediator-regulated transcription through the +1 nucleosome. (2012) Molecular Cell. 48(6):837-48.

Nock A, Ascano JA, Barrero MJ and Malik S.

DOI

Alu-repeat mediated regulation of DIEXF expression in cell differentiation and cancer. (2020) Epigenetics 15(6-7):765-779.

Martín B, Pappa S. Díez-Villanueva A, Mallona I, Custodio J, Barrero MJ, Peinado MA, Jordà M.

DOI

Periostin: A matricellular protein with multiple functions in cancer development and progression. Front. Oncol. (2018) 8:225

González-González L., Alonso J.

PUBMED DOI

DNA Methylomes Reveal Biological Networks Involved in Human Eye Development, Functions and Associated Disorders. Sci Rep. (2017) 7(1):11762.

Berdasco M, Gómez A, Rubio MJ, Català-Mora J, Zanón-Moreno V, Lopez M, Hernández C, Yoshida S, Nakama T, Ishikawa K, Ishibashi T, Boubekeur AM, Louhibi L, Pujana MA, Sayols S, Setien F, Corella D, de Torres C, Parareda A, Mora J, Zhao L, Zhang K, Lleonart ME, Alonso J, Simó R, Caminal JM, Esteller M.

PUBMED DOI

EWS-FLI1-mediated suppression of the RAS-antagonist Sprouty 1 (SPRY1) confers aggressiveness to Ewing sarcoma. Oncogene (2017) 36(6):766-776.

Cidre-Aranaz F, Grünewald TG, Surdez D, García-García L, Carlos Lázaro J, Kirchner T, González-González L, Sastre A, García-Miguel P, López-Pérez SE, Monzón S, Delattre O, Alonso J.

PUBMED DOI

DICER1 mutation and tumors associated with a famílial tumor predisposition syndrome: practical considerations. Familial Cancer (2017) 16:291-294

Bardón-Cancho E.J., Haro-Díaz A., Alonso-García de la Rosa J., Huerta-Aragonés J., García-Morín M., González-Martínez F., Garrido-Colino C.

PUBMED DOI

Familial retinoblastoma due to intronic LINE-1 insertion causes aberrant and non-canonical mRNA splicing of the RB1 gene. J Hum Genet (2016) 61(5):463-6.

Rodríguez-Martín C., Cidre-Aranaz F., Fernández-Teijeiro A., Gómez-Mariano G., de la Vega L., Ramos P., Zaballos A., Monzón S., Alonso J.

PUBMED DOI

Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA-microsatellite. Nature Genetics (2015) 47(9):1073-8.

Grünewald T.G.P., Bernard V., Gilardi-Hebenstreit P., Raynal V., Surdez D., Aynaud M.M., Mirabeau O., Cidre-Aranaz F., Tirode F., Zaidi S., Perot G., Jonker A.H., Lucchesi C., Le Deley M.C., Oberlin O., Marec-Bérard P., Véron A.S., Reynaud S., Lapouble E., Boeva V., Frio T.R, Alonso J., Bhatia S., Pierron G., Cancel-Tassin G., Cussenot O., Cox D.G., Morton L.M., Machiela M., Chanock S.J., Charnay P., Delattre O.

PUBMED DOI

EWS/FLI1 target genes and therapeutic opportunities in Ewing sarcoma. Front. Oncol. (2015)

Cidre-Aranaz F., Alonso J.

PUBMED DOI

Lysyl oxidase is downregulated by the EWS/FLI1 oncoprotein and its propeptide domain displays tumor supressor activities in ewing sarcoma cells. PLoS One (2013) 10.1371/journal.pone.0066281

Agra N., Cidre F., García-García L., de la Parra J., Alonso J.

PUBMED DOI

SpainUDP: The Spanish Undiagnosed Rare Diseases Program. Int J Environ Res Public Health. (2018) 15(8). pii: E1746.

López-Martín E, Martínez-Delgado B, Bermejo-Sánchez E, Alonso J, SpainUDP Network, Posada M.

PUBMED DOI

Selective inhibition of plasma membrane calcium ATPase4 improves angiogénesis and vascular reperfusion. 2017. J. Mol. Cell. Cardiol. 109: 38-47.

Kurusamy S., López-Maderuelo D., Little R., Cadagan D., Savage A.M., Ihugba J.C., Baggott RR, Rowther FB., Martínez-Martínez S, Gómez-del Arco P., Murcott C., Wang W., Nistal F.J., Oceandy D, Neyses L, Wilkinson R.N., Cartwright EJ, Redondo J.M. and A.L. Armesilla.

PUBMED DOI

The Chromatin Remodeling Complex Chd4/NuRD controls striated muscle identity and metabolic homeostasis. 2016. Cell Metabolism. 23: 881-892.

Gómez-del Arco P*., Perdiguero E., Yunes-Leites P.S., Acín-Pérez R., Zeini M., García-Gómez A., Sreenivasan K., Jiménez-Alcázar M., Segalés J., López-Maderuelo D., Ornés B., Jiménez-Borreguero L.J., D´Amato G., Enshell-Seijffers D., Morgan B., Georgopoulos K., Islam AbuL B.M.M.K., Braun T., de la Pompa J.L., Kim J., Enriquez J.A., Ballestar E,, Muñoz-Cánoves P. and Redondo J.M*. *corresponding authors.

PUBMED DOI

Sequential ligand-dependent Notch signaling activation regulates valve primordium formation and morphogenesis. 2016. Circulation Research. 118 (10): 1480-1497.

MacGrogan D., D´Amato G., Travisano S., Martinez-Poveda B., Luxán G., del Monte-Nieto G., Papoutsi T., Sbroggio M., Bou V., Gómez-del Arco P., Gómez M.J., Zhou B., Redondo J.M., Jiménez-Borreguero L.J., de la Pompa J.L.

PUBMED DOI

Investigación