Protegemos tu salud a través de la Ciencia
Recursos del IIER
Diagnóstico genético
Diagnóstico Retinoblastoma
Diagnóstico Déficit de alfa-1 antitripsina
Diagnóstico genético de Epidermólisis Bullosa
Diagnóstico Programa Casos No Diagnosticados (SpainUDP)
Diagnóstico de tumores de ovario de células de la granulosa
Publicaciones destacadas
Thomas GP Grünewald, Marta Alonso, Sofia Avnet, Ana Banito, Stefan Burdach, Florencia Cidre‐Aranaz,Gemma Di Pompo, Martin Distel, Heathcliff Dorado‐Garcia, Javier Garcia‐Castro, Laura González‐González, Agamemnon E Grigoriadis, Merve Kasan, Christian Koelsche, Manuela Krumbholz, Fernando Lecanda, Silvia Lemma, Dario L Longo, Claudia Madrigal‐Esquivel, Álvaro Morales‐Molina, Julian Musa, Shunya Ohmura, Benjamin Ory, Miguel Pereira‐Silva, Francesca Perut, Rene Rodriguez, Carolin Seeling, Nada Al Shaaili, Shabnam Shaabani, Kristina Shiavone, Snehadri Sinha, Eleni M Tomazou, Marcel Trautmann, Maria Vela,Yvonne MH Versleijen‐Jonkers, Julia Visgauss, Marta Zalacain, Sebastian J Schober, Andrej Lissat, William R English, Nicola Baldini, Dominique Heymann. Sarcoma treatment in the era of molecular medicine EMBO Mol Med 2020; 12(11):e11131.
Thomas GP Grünewald, Marta Alonso, Sofia Avnet, Ana Banito, Stefan Burdach, Florencia Cidre‐Aranaz,Gemma Di Pompo, Martin Distel, Heathcliff Dorado‐Garcia, Javier Garcia‐Castro, Laura González‐González, Agamemnon E Grigoriadis, Merve Kasan, Christian Koelsche, Manuela Krumbholz, Fernando Lecanda, Silvia Lemma, Dario L Longo, Claudia Madrigal‐Esquivel, Álvaro Morales‐Molina, Julian Musa, Shunya Ohmura, Benjamin Ory, Miguel Pereira‐Silva, Francesca Perut, Rene Rodriguez, Carolin Seeling, Nada Al Shaaili, Shabnam Shaabani, Kristina Shiavone, Snehadri Sinha, Eleni M Tomazou, Marcel Trautmann, Maria Vela,Yvonne MH Versleijen‐Jonkers, Julia Visgauss, Marta Zalacain, Sebastian J Schober, Andrej Lissat, William R English, Nicola Baldini, Dominique Heymann. Sarcoma treatment in the era of molecular medicine EMBO Mol Med 2020; 12(11):e11131.
PUBMED DOIAlvaro Morales-Molina, Miguel Ángel Rodríguez-Milla, Alicia Gimenez-Sanchez, Ana Judith Perisé-Barrios, Javier García-Castro. Cellular Virotherapy Increases Tumor-Infiltrating Lymphocytes (TIL) and Decreases their PD-1+ Subsets in Mouse Immunocompetent Models Cancers 2020 Jul; 12(7): 1920.
Alvaro Morales-Molina, Miguel Ángel Rodríguez-Milla, Alicia Gimenez-Sanchez, Ana Judith Perisé-Barrios, Javier García-Castro. Cellular Virotherapy Increases Tumor-Infiltrating Lymphocytes (TIL) and Decreases their PD-1+ Subsets in Mouse Immunocompetent Models Cancers 2020 Jul; 12(7): 1920.
PUBMED DOIAna Gómez, David Sardón, Teresa Cejalvo, Fernando Vázquez, Javier García-Castro, Ana Judith Perisé-Barrios. Biodistribution Analysis of Oncolytic Adenoviruses in Canine Patient Necropsy Samples Treated with Cellular Virotherapy Molecular Therapy: Oncolytics Vol. 18 September 2020: 525-534.
Ana Gómez, David Sardón, Teresa Cejalvo, Fernando Vázquez, Javier García-Castro, Ana Judith Perisé-Barrios. Biodistribution Analysis of Oncolytic Adenoviruses in Canine Patient Necropsy Samples Treated with Cellular Virotherapy Molecular Therapy: Oncolytics Vol. 18 September 2020: 525-534.
PUBMED DOIJiménez-García L, Higueras MÁ, Herranz S, Hernández-López M, Luque A, de Las Heras B, Hortelano S. A hispanolone-derived diterpenoid inhibits M2-Macrophage polarization in vitro via JAK/STAT and attenuates chitin induced inflammation in vivo. Biochem Pharmacol. 2018 Aug;154:373-383
Jiménez-García L, Higueras MÁ, Herranz S, Hernández-López M, Luque A, de Las Heras B, Hortelano S. A hispanolone-derived diterpenoid inhibits M2-Macrophage polarization in vitro via JAK/STAT and attenuates chitin induced inflammation in vivo. Biochem Pharmacol. 2018 Aug;154:373-383
PUBMED DOIJiménez-García L, Herranz S, Higueras MA, Luque A, Hortelano S. Tumor suppressor ARF regulates tissue microenvironment and tumor growth through modulation of macrophage polarization. Oncotarget. 2016 Oct 11;7(41):66835-66850.
Jiménez-García L, Herranz S, Higueras MA, Luque A, Hortelano S. Tumor suppressor ARF regulates tissue microenvironment and tumor growth through modulation of macrophage polarization. Oncotarget. 2016 Oct 11;7(41):66835-66850.
PUBMED DOIJiménez-García L, Través PG, López-Fontal R, Herranz S, Higueras MA, de Las Heras B, Hortelano S, Luque A. 8,9-Dehydrohispanolone-15,16-lactol diterpene prevents LPS-triggered inflammatory responses by inhibiting endothelial activation. Biochem J. 2016 Jul 15;473(14):2061-71.
Jiménez-García L, Través PG, López-Fontal R, Herranz S, Higueras MA, de Las Heras B, Hortelano S, Luque A. 8,9-Dehydrohispanolone-15,16-lactol diterpene prevents LPS-triggered inflammatory responses by inhibiting endothelial activation. Biochem J. 2016 Jul 15;473(14):2061-71.
PUBMED DOIGarcía-Quintans N, Prieto I, Sánchez-Ramos C, Luque A, Arza E, Olmos Y, Monsalve M. Regulation of endothelial dynamics by PGC-1α relies on ROS control of VEGF-A signaling. Free Radic Biol Med. 2016 Apr;93:41-51
García-Quintans N, Prieto I, Sánchez-Ramos C, Luque A, Arza E, Olmos Y, Monsalve M. Regulation of endothelial dynamics by PGC-1α relies on ROS control of VEGF-A signaling. Free Radic Biol Med. 2016 Apr;93:41-51
PUBMED DOIAbós B, Wang T, Castro R, Granja AG, Leal E, Havixbeck J, Luque A, Barreda DR, Secombes CJ, Tafalla C. Distinct Differentiation Programs Triggered by IL-6 and LPS in Teleost IgM(+) B Cells in The Absence of Germinal Centers. Sci Rep. 2016 Aug 2;6:30004
Abós B, Wang T, Castro R, Granja AG, Leal E, Havixbeck J, Luque A, Barreda DR, Secombes CJ, Tafalla C. Distinct Differentiation Programs Triggered by IL-6 and LPS in Teleost IgM(+) B Cells in The Absence of Germinal Centers. Sci Rep. 2016 Aug 2;6:30004
PUBMED DOIMaría Luisa Franco, Cristina Melero, Esther Sarasola, Alfonso Luque, María García-Barcina and Marçal Vilar. Mutations in TrkA Causing Congenital Insensitivity to Pain with Anhidrosis (CIPA) Induce Mutation-Dependent Misfolding, Aggregation and Cell Death. J Biol Chem. 2016 Aug 22. pii: jbc.M116.722587
María Luisa Franco, Cristina Melero, Esther Sarasola, Alfonso Luque, María García-Barcina and Marçal Vilar. Mutations in TrkA Causing Congenital Insensitivity to Pain with Anhidrosis (CIPA) Induce Mutation-Dependent Misfolding, Aggregation and Cell Death. J Biol Chem. 2016 Aug 22. pii: jbc.M116.722587
PUBMED DOIα-Hispanolol sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis via death receptor up-regulation. Mota A, Jiménez-Garcia L, Herránz S, de Las Heras B, Hortelano S. Toxicol Appl Pharmacol. 2015 Aug 1;286(3):168-77.
α-Hispanolol sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis via death receptor up-regulation. Mota A, Jiménez-Garcia L, Herránz S, de Las Heras B, Hortelano S. Toxicol Appl Pharmacol. 2015 Aug 1;286(3):168-77.
PUBMED DOICritical role of p38 MAPK in IL-4-induced alternative activation of peritoneal macrophages. Jiménez-Garcia L, Herránz S, Luque A, Hortelano S. Eur J Immunol. 2015 Jan;45(1):273-86
Critical role of p38 MAPK in IL-4-induced alternative activation of peritoneal macrophages. Jiménez-Garcia L, Herránz S, Luque A, Hortelano S. Eur J Immunol. 2015 Jan;45(1):273-86
PUBMED DOIIL10 released by a new inflammation-regulated lentiviral system efficiently attenuates zymosan-induced arthritis. Garaulet G, Alfranca A, Torrente M, Escolano A, López-Fontal R, Hortelano S, Redondo JM, Rodríguez A. Mol Ther. 2013 Jan;21(1):119-30.
IL10 released by a new inflammation-regulated lentiviral system efficiently attenuates zymosan-induced arthritis. Garaulet G, Alfranca A, Torrente M, Escolano A, López-Fontal R, Hortelano S, Redondo JM, Rodríguez A. Mol Ther. 2013 Jan;21(1):119-30.
PUBMED DOICritical role of the death receptor pathway in the antitumoral effects induced by hispanolone derivatives. Través PG, López-Fontal R, Cuadrado I, Luque A, Boscá L, de las Heras B, Hortelano S. Oncogene. 2013 Jan 10;32(2):259-68.
Critical role of the death receptor pathway in the antitumoral effects induced by hispanolone derivatives. Través PG, López-Fontal R, Cuadrado I, Luque A, Boscá L, de las Heras B, Hortelano S. Oncogene. 2013 Jan 10;32(2):259-68.
PUBMED DOIMeeting report of the 17th Spanish Society for Developmental Biology Meeting (SEBD2020). (2021) Int J Dev Biol.
Araújo SJ, Almudi I, Bozal-Basterra L, Casares F, Casas-Tintó S, Escalante A, García-Moreno F, Losada-Pérez M, Maeso I, Marcon L, Ocaña O, Pampliega O, Rada-Iglesias Á, Rayon T, Sharpe J, Sutherland JD, Villa Del Campo C, Barrio R.
PUBMED DOIDNA Methylomes Reveal Biological Networks Involved in Human Eye Development, Functions and Associated Disorders. Sci Rep. (2017) 7(1):11762.
Berdasco M, Gómez A, Rubio MJ, Català-Mora J, Zanón-Moreno V, Lopez M, Hernández C, Yoshida S, Nakama T, Ishikawa K, Ishibashi T, Boubekeur AM, Louhibi L, Pujana MA, Sayols S, Setien F, Corella D, de Torres C, Parareda A, Mora J, Zhao L, Zhang K, Lleonart ME, Alonso J, Simó R, Caminal JM, Esteller M.
PUBMED DOIMechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP. (2022) Nature Communications.
García-García M, Sánchez-Perales S, Casas-Tintó S, Görlich D, Echarri A and del Pozo MA. Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP. (2022) Nature Communications. doi: 10.1038/s41467-022-28693-y. PMID: 35246520
PUBMED DOISequential ligand-dependent Notch signaling activation regulates valve primordium formation and morphogenesis. 2016. Circulation Research. 118 (10): 1480-1497.
MacGrogan D., D´Amato G., Travisano S., Martinez-Poveda B., Luxán G., del Monte-Nieto G., Papoutsi T., Sbroggio M., Bou V., Gómez-del Arco P., Gómez M.J., Zhou B., Redondo J.M., Jiménez-Borreguero L.J., de la Pompa J.L.
PUBMED DOIEl Área de Genética Humana (AGH) adscrita al Instituto de Investigación en Enfermedades Raras, cuenta con un Servicio de Diagnóstico Genético en el que se ofertan servicios para el diagnóstico de diferentes enfermedades genéticas. El AGH aporta experiencia en numerosas técnicas de secuenciación masiva y análisis de datos de gran proyección en la recién iniciada era post-genómica.
Beatriz Martínez Delgado Gema Gómez Mariano
bmartinezd@isciii.es ggomezm@isciii.es
Telf: 91 8223152 Telf: 91 8223101