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| Health Problem | Toxic Oil Syndrome (TOS) | ||
| Definition | Interstitial pattern in Chest X-Ray, Eosinophilia, myalgias as acute form of the diseases and myalgias and eosinophilia with one of these: scleroderma, neuropathy, pulmonary hypertension | ||
| Main Organs Affected | Systemic Disease, Lung | ||
| Symptoms | Respiratory failure, Hepatomegaly, Myalgias, Sicca syndrome, Skin rash | ||
| Person, place and time | All the population exposed; Spain; 1981 | ||
| Nº of Affected | 19,995 | ||
| Causal Agent | Fatty acid anilides and Phenyl-amino-propanediol diesters | Confirmed | No |
| Routes of Exposure | Ingestion | Sources of Exposure | Oil |
| Vehicle of the Outbreak | Rapeseed Oil | ||
| Follow-up? | Yes | Nº of Years | 18 |
| People under Follow-up | Total of the Cohort affected |
Posada M., Phillen R.M., Abaitua I., Diez Ruiz-Navarro M., Abraira V., Pozo F., Pla R., Pollán M., Sicilia J.M., Azpeitia P., Woodruff R. and Kilbourne E.M. 1994. "Factors Associated with Pathogenicity of Oils Related to the Toxic Oil Syndrome Epidemic in Spain". Epidemiology - 5 (4) : 404-409
Phillen R.M. and Posada M. 1993. "Toxic Oil Syndrome and Eosinophilia Myalgia Syndrome WHO Meeting Report ". Sem. Arthritis Rheum. 23: 104-124.
Posada M., Abaitua I., Kilboune E.M., Tabuenca J.M., Diaz de Rojas F., Castro M. and Alonso J.M. 1989. "Late cases of Toxic Oil Syndrome : Evdence that the aetiological agent persisted in oil stored for up to one year". Fd. Chem. Toxicol. 27 (8) : 517-521.
Kilbourne E.M., Bernert J.T., Posada M., Hill R.H., Abaitua I. and Kilbourne B.W. et al. 1988. "Chemical correlates of pathogenicity of oils related to TOS epidemic in Spain". Am. J. Epidemiol. 127 (6) : 1210-1227.
Hill RH, Schurz HH, Posada de la Paz M, et al. Possible etiologic agents for toxic oil syndrome: fatty acid esters of 3-(N-phenylamino)-1,2-propanediol. Arch Environ Contam Toxicol 1995;28(2):259-64
Posada de la Paz M, Philen RM, Schurz HH, et al. Epidemiologic evidence for a new class of compounds associated with Toxic Oil Syndrome. Epidemiology 1999; 10(2): 130-134
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Síndrome del Aceite Tóxico: Una nueva enfermedad. Una prespectiva
de interacción entre ambiente y
huesped.
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